Ontology highlight
ABSTRACT:
SUBMITTER: He C
PROVIDER: S-EPMC4992065 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
He Chunbai C Duan Xiaopin X Guo Nining N Chan Christina C Poon Christopher C Weichselbaum Ralph R RR Lin Wenbin W
Nature communications 20160817
Advanced colorectal cancer is one of the deadliest cancers, with a 5-year survival rate of only 12% for patients with the metastatic disease. Checkpoint inhibitors, such as the antibodies inhibiting the PD-1/PD-L1 axis, are among the most promising immunotherapies for patients with advanced colon cancer, but their durable response rate remains low. We herein report the use of immunogenic nanoparticles to augment the antitumour efficacy of PD-L1 antibody-mediated cancer immunotherapy. Nanoscale c ...[more]