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Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy.

ABSTRACT: The one-step self-assembly preparation of multifunctional gadolinium (Gd)-ytterbium (Yb) mixed-metal nanoscale coordination polymers (NCPs) with Ru[4,4'-(COOH)₂bpy]₃²⁺ (L_Ru , bpy = bipyridyl) as a ligand is reported. The Gd/Yb ratio in the NCPs is easily tuned by their ratio in the precursors while the self-limiting growth is realized with the high coordination valence and rigid steric structure of the precursors. The inherent properties of the precursors, including the magnetic resonance (MR) response of Gd³⁺, the X-ray attenuation properties of Yb³⁺, and the red fluorescence and the singlet-oxygen generation of L_Ru , are well retained in the mixed-metal NCPs. In vivo fluorescence-MR-X-ray computed tomography (CT), triple-modality imaging and photodynamic therapy (PDT) are achieved using the mixed-metal NCPs as a probe. The triple-modality imaging integrates the high sensitivity of red fluorescence imaging, the deep penetration of MR imaging, and the 3D spatial resolution of CT imaging, thus providing comprehensive and complementary imaging information and facilitating the efficient imaging-guided PDT. For the first time, triple-modality imaging and a PDT agent were prepared with an easy and robust procedure, a tunable mixed-metal ratio, a high yield, and endogenous signal units.

SUBMITTER: Wang YM

PROVIDER: S-EPMC5465558 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature

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Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy.

Wang Yong-Mei YM Liu Wei W Yin Xue-Bo XB

Chemical science 20170310 5

The one-step self-assembly preparation of multifunctional gadolinium (Gd)-ytterbium (Yb) mixed-metal nanoscale coordination polymers (NCPs) with Ru[4,4'-(COOH)2bpy]32+ (LRu , bpy = bipyridyl) as a ligand is reported. The Gd/Yb ratio in the NCPs is easily tuned by their ratio in the precursors while the self-limiting growth is realized with the high coordination valence and rigid steric structure of the precursors. The inherent properties of the ...[more]

PMID: 28626558

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Project description:Gliomas are one of the most common types of primary brain tumors. Despite recent advances in the combination of surgery, radiotherapy, systemic therapy (chemotherapy, targeted therapy) and supportive therapy in the multimodal treatment of gliomas, the overall prognosis remains poor and the long?term survival rate is low. Thus, it is crucial to develop a novel glioma management method. Due to its relatively non?invasive, selective and repeatable characteristics, photodynamic therapy (PDT) has been investigated for glioma therapy in the past decade, exhibiting higher selectivity and lower side effects compared with those of conventional therapy. However, most of the photosensitizers (PSs) are highly hydrophobic, leading to poor water solubility, rapid degradation with clearance in blood circulation and ultimately, low bioavailability. In the present study, hydrophilic polyethylene glycol (PEG)?chlorin e6 (Ce6) chelated gadolinium ion (Gd3+) nanoparticles (PEG?Ce6?Gd NPs) were synthesized via a chelation and self?assembly process. Initially, the cell cytotoxicity of PEG?Ce6?Gd NPs was evaluated with or without laser irradiation. The in vitro study demonstrated the lack of toxicity of PEG?Ce6?Gd NPs to tumor cells in the absence of laser irradiation. However, its toxicity was enhanced under laser irradiation. Moreover, the size and weight of brain tumors were significantly decreased in mice with glioma xenografts, which was further confirmed via histological analysis. Subsequently, the results indicated that the PEG?Ce6?Gd NPs had a favorable T1?weighted contrast performance (0.43 mg ml?1 s?1) and were observed to have signi?cant contrast enhancement at the tumor site from 0.25 to 1 h post?injection in vivo. The favorable MRI, as well as the synergetic photodynamic antitumor effect and antineoplastic ability of PEG?Ce6?Gd NPs was identified. It was suggested that PEG?Ce6?Gd NPs had great potential in the diagnosis and PDT treatment of gliomas, and possibly other cancer types, with prospects of clinical application in the near future.

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Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy.

Publications

Multifunctional mixed-metal nanoscale coordination polymers for triple-modality imaging-guided photodynamic therapy.

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