Unknown

Dataset Information

0

Genome-wide association study identifies 14 novel risk alleles associated with basal cell carcinoma.

ABSTRACT: Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10(-8), logistic regression). These newly associated SNPs lie within predicted keratinocyte regulatory elements and in expression quantitative trait loci; furthermore, we identify candidate genes and non-coding RNAs involved in telomere maintenance, immune regulation and tumour progression, providing deeper insight into the pathogenesis of BCC.

SUBMITTER: Chahal HS 

PROVIDER: S-EPMC4992160 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Basal cell carcinoma (BCC) is the most common cancer worldwide with an annual incidence of 2.8 million cases in the United States alone. Previous studies have demonstrated an association between 21 distinct genetic loci and BCC risk. Here, we report the results of a two-stage genome-wide association study of BCC, totalling 17,187 cases and 287,054 controls. We confirm 17 previously reported loci and identify 14 new susceptibility loci reaching genome-wide significance (P<5 × 10(-8), logistic reg  ...[more]

Similar Datasets

Unknown Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.
| S-EPMC3159556 | biostudies-literature
Unknown Genome-wide association identifies a novel locus for delirium risk.
| S-EPMC5993590 | biostudies-literature
Unknown A genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.
| S-EPMC2367449 | biostudies-literature
Unknown Genome-Wide Association Study in Irradiated Childhood Cancer Survivors Identifies HTR2A for Subsequent Basal Cell Carcinoma.
| S-EPMC6708785 | biostudies-literature
Unknown Genome-wide association study identifies multiple risk loci for renal cell carcinoma.
| S-EPMC5472706 | biostudies-literature
Unknown Genome-wide association study identifies novel risk loci for apical periodontitis.
| S-EPMC9901028 | biostudies-literature
Unknown A Genome-wide Association Study Identifies Risk Alleles in Plasminogen and P4HA2 Associated with Giant Cell Arteritis.
| S-EPMC5223025 | biostudies-literature
Unknown A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer.
| S-EPMC3493132 | biostudies-literature
Unknown Genome-wide association identifies novel ROP risk loci in a multiethnic cohort.
| S-EPMC10794688 | biostudies-literature
Unknown Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma.
| S-EPMC4960294 | biostudies-literature