Identifying a maximum tolerated contour in two-dimensional dose finding.
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ABSTRACT:
SUBMITTER: Wages NA
PROVIDER: S-EPMC4993696 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Publications
Identifying a maximum tolerated contour in two-dimensional dose finding.
Statistics in medicine 20160222 2
The majority of phase I methods for multi-agent trials have focused on identifying a single maximum tolerated dose combination (MTDC) among those being investigated. Some published methods in the area have been based on the notion that there is no unique MTDC and that the set of dose combinations with acceptable toxicity forms an equivalence contour in two dimensions. Therefore, it may be of interest to find multiple MTDCs for further testing for efficacy in a phase II setting. In this paper, we ...[more]
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| S-EPMC5096994 | biostudies-literature
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| S-SCDT-EMM-2019-11416 | biostudies-other
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| S-EPMC7071774 | biostudies-literature
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| S-EPMC3463734 | biostudies-literature