Ontology highlight
ABSTRACT:
SUBMITTER: Drougard A
PROVIDER: S-EPMC4994119 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Drougard Anne A Fournel Audren A Marlin Alysson A Meunier Etienne E Abot Anne A Bautzova Tereza T Duparc Thibaut T Louche Katie K Batut Aurelie A Lucas Alexandre A Le-Gonidec Sophie S Lesage Jean J Fioramonti Xavier X Moro Cedric C Valet Philippe P Cani Patrice D PD Knauf Claude C
Scientific reports 20160823
Apelin is a bioactive peptide involved in the control of energy metabolism. In the hypothalamus, chronic exposure to high levels of apelin is associated with an increase in hepatic glucose production, and then contributes to the onset of type 2 diabetes. However, the molecular mechanisms behind deleterious effects of chronic apelin in the brain and consequences on energy expenditure and thermogenesis are currently unknown. We aimed to evaluate the effects of chronic intracerebroventricular (icv) ...[more]