Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.
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ABSTRACT:
SUBMITTER: Garaude J
PROVIDER: S-EPMC4994870 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Publications
Mitochondrial respiratory-chain adaptations in macrophages contribute to antibacterial host defense.
Garaude Johan J Acín-Pérez Rebeca R Martínez-Cano Sarai S Enamorado Michel M Ugolini Matteo M Nistal-Villán Estanislao E Hervás-Stubbs Sandra S Pelegrín Pablo P Sander Leif E LE Enríquez José A JA Sancho David D
Nature immunology 20160627 9
Macrophages tightly scale their core metabolism after being activated, but the precise regulation of the mitochondrial electron-transport chain (ETC) and its functional implications are currently unknown. Here we found that recognition of live bacteria by macrophages transiently decreased assembly of the ETC complex I (CI) and CI-containing super-complexes and switched the relative contributions of CI and CII to mitochondrial respiration. This was mediated by phagosomal NADPH oxidase and the rea ...[more]
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