Ontology highlight
ABSTRACT:
SUBMITTER: Guo Q
PROVIDER: S-EPMC4996037 | biostudies-literature | 2016
REPOSITORIES: biostudies-literature
Guo Qi Q Chen Yusi Y Guo Lijuan L Jiang Tiejian T Lin Zhangyuan Z
Bone research 20160824
Age-related osteoporosis is associated with the reduced capacity of bone marrow mesenchymal stem cells (BMSCs) to differentiate into osteoblasts instead of adipocytes. However, the molecular mechanisms that decide the fate of BMSCs remain unclear. In our study, microRNA-23a, and microRNA-23b (miR-23a/b) were found to be markedly downregulated in BMSCs of aged mice and humans. The overexpression of miR-23a/b in BMSCs promoted osteogenic differentiation, whereas the inhibition of miR-23a/b increas ...[more]