Ontology highlight
ABSTRACT:
SUBMITTER: Levran O
PROVIDER: S-EPMC4996315 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Levran Orna O Randesi Matthew M Peles Einat E Correa da Rosa Joel J Ott Jurg J Rotrosen John J Adelson Miriam M Kreek Mary Jeanne MJ
Pharmacogenomics 20160607 9
<h4>Aim</h4>This study was designed to determine whether polymorphisms in acetylcholine receptors contribute to opioid dependence and/or cocaine dependence.<h4>Patients & methods</h4>The sample (n = 1860) was divided by drug and ancestry, and 55 polymorphisms (nine genes) were analyzed.<h4>Results</h4>Of the 20 SNPs that showed nominally significant associations, the association of the African-specific CHRM4 SNP rs2229163 (Asn417=) with cocaine dependence survived correction for multiple testing ...[more]