Ontology highlight
ABSTRACT:
SUBMITTER: Pieters T
PROVIDER: S-EPMC4996431 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Pieters Tim T Goossens Steven S Haenebalcke Lieven L Andries Vanessa V Andries Vanessa V Stryjewska Agata A De Rycke Riet R Lemeire Kelly K Hochepied Tino T Huylebroeck Danny D Berx Geert G Stemmler Marc P MP Wirth Dagmar D Haigh Jody J JJ van Hengel Jolanda J van Roy Frans F
PLoS genetics 20160824 8
E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs). E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment. To further explore the roles of cell adhesion molecules during mESC differentiation, we focused on p120 catenin (p120ctn). Although one key function of p120ctn is to stabilize and regulate cadherin-mediated cell-cell adhesion, it has many additional function ...[more]