Ontology highlight
ABSTRACT:
SUBMITTER: Yang SH
PROVIDER: S-EPMC4997635 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Yang Shih-Hung SH Kuo Ting-Chun TC Wu Hsu H Guo Jhe-Cyuan JC Hsu Chiun C Hsu Chih-Hung CH Tien Yu-Wen YW Yeh Kun-Huei KH Cheng Ann-Lii AL Kuo Sung-Hsin SH
World journal of gastroenterology 20160801 32
Pancreatic cancer is highly lethal. Current research that combines radiation with targeted therapy may dramatically improve prognosis. Cancerous cells are characterized by unstable genomes and activation of DNA repair pathways, which are indicated by increased phosphorylation of numerous factors, including H2AX, ATM, ATR, Chk1, Chk2, DNA-PKcs, Rad51, and Ku70/Ku80 heterodimers. Radiotherapy causes DNA damage. Cancer cells can be made more sensitive to the effects of radiation (radiosensitization ...[more]