Ontology highlight
ABSTRACT:
SUBMITTER: Eroukhmanoff J
PROVIDER: S-EPMC4997685 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Eroukhmanoff Juliette J Castinetti Frederic F Penel Nicolas N Salas Sebastien S
BMC cancer 20160824
<h4>Background</h4>While hypothyroidism has frequently been reported with the use of TKIs, the thyroid-stimulating hormone (TSH) suppressing effect of TKIs is rare, except for thyroiditis. We describe a case with progressive recurrent chordoma who initially became hyperthyroid in a context of autoimmunity under sorafenib treatment and later under imatinib treatment.<h4>Case presentation</h4>A 57-year-old man with lumbar chordoma began daily treatment of 800 mg sorafenib. He did not have any othe ...[more]