Ontology highlight
ABSTRACT:
SUBMITTER: Soriano EV
PROVIDER: S-EPMC4998004 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Developmental cell 20160801 4
Atypical protein kinase C (aPKC) is a key apical-basal polarity determinant and Par complex component. It is recruited by Par3/Baz (Bazooka in Drosophila) into epithelial apical domains through high-affinity interaction. Paradoxically, aPKC also phosphorylates Par3/Baz, provoking its relocalization to adherens junctions (AJs). We show that Par3 conserved region 3 (CR3) forms a tight inhibitory complex with a primed aPKC kinase domain, blocking substrate access. A CR3 motif flanking its PKC conse ...[more]