Ontology highlight
ABSTRACT:
SUBMITTER: Saavedra K
PROVIDER: S-EPMC5000676 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
International journal of molecular sciences 20160805 8
Major depressive disorder (MDD) is a chronic disease whose neurological basis and pathophysiology remain poorly understood. Initially, it was proposed that genetic variations were responsible for the development of this disease. Nevertheless, several studies within the last decade have provided evidence suggesting that environmental factors play an important role in MDD pathophysiology. Alterations in epigenetics mechanism, such as DNA methylation, histone modification and microRNA expression co ...[more]