Ontology highlight
ABSTRACT:
SUBMITTER: van Wietmarschen N
PROVIDER: S-EPMC5001594 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
van Wietmarschen Niek N Lansdorp Peter M PM
Nucleic acids research 20160516 14
Sister chromatid exchanges (SCEs) are considered sensitive indicators of genome instability. Detection of SCEs typically requires cells to incorporate bromodeoxyuridine (BrdU) during two rounds of DNA synthesis. Previous studies have suggested that SCEs are induced by DNA replication over BrdU-substituted DNA and that BrdU incorporation alone could be responsible for the high number of SCE events observed in cells from patients with Bloom syndrome (BS), a rare genetic disorder characterized by m ...[more]