Ontology highlight
ABSTRACT:
SUBMITTER: Spahr H
PROVIDER: S-EPMC5001613 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Spåhr Henrik H Rozanska Agata A Li Xinping X Atanassov Ilian I Lightowlers Robert N RN Chrzanowska-Lightowlers Zofia M A ZM Rackham Oliver O Larsson Nils-Göran NG
Nucleic acids research 20160628 14
LRPPRC is a protein that has attracted interest both for its role in post-transcriptional regulation of mitochondrial gene expression and more recently because numerous mutated variants have been characterized as causing severe infantile mitochondrial neurodegeneration. LRPPRC belongs to the pentatricopeptide repeat (PPR) protein family, originally defined by their RNA binding capacity, and forms a complex with SLIRP that harbours an RNA recognition motif (RRM) domain. We show here that LRPPRC d ...[more]