Ontology highlight
ABSTRACT:
SUBMITTER: Narayanan A
PROVIDER: S-EPMC4399498 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Narayanan Anoop A Kumar Shivesh S Evrard Amanda N AN Paul Lake N LN Yernool Dinesh A DA
Nature communications 20140101
Two-component signal transduction systems consist of pairs of histidine kinases and response regulators, which mediate adaptive responses to environmental cues. Most activated response regulators regulate transcription by binding tightly to promoter DNA via a phosphorylation-triggered inactive-to-active transition. The molecular basis for formation of stable response regulator-DNA complexes that precede the assembly of RNA polymerases is unclear. Here, we present structures of DNA complexed with ...[more]