Ontology highlight
ABSTRACT:
SUBMITTER: Mayer EA
PROVIDER: S-EPMC5001844 | biostudies-literature | 2015 Oct
REPOSITORIES: biostudies-literature
Mayer Emeran A EA Labus Jennifer S JS Tillisch Kirsten K Cole Steven W SW Baldi Pierre P
Nature reviews. Gastroenterology & hepatology 20150825 10
Despite an extensive body of reported information about peripheral and central mechanisms involved in the pathophysiology of IBS symptoms, no comprehensive disease model has emerged that would guide the development of novel, effective therapies. In this Review, we will first describe novel insights into some key components of brain-gut interactions, starting with the emerging findings of distinct functional and structural brain signatures of IBS. We will then point out emerging correlations betw ...[more]