Ontology highlight
ABSTRACT:
SUBMITTER: Zaveri NT
PROVIDER: S-EPMC5001850 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Journal of medicinal chemistry 20160314 15
In the two decades since the discovery of the nociceptin opioid receptor (NOP) and its ligand, nociceptin/orphaninFQ (N/OFQ), steady progress has been achieved in understanding the pharmacology of this fourth opioid receptor/peptide system, aided by genetic and pharmacologic approaches. This research spawned an explosion of small-molecule NOP receptor ligands from discovery programs in major pharmaceutical companies. NOP agonists have been investigated for their efficacy in preclinical models of ...[more]