Ontology highlight
ABSTRACT:
SUBMITTER: Manago F
PROVIDER: S-EPMC5001893 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Managò Francesca F Mereu Maddalena M Mastwal Surjeet S Mastrogiacomo Rosa R Scheggia Diego D Emanuele Marco M De Luca Maria A MA Weinberger Daniel R DR Wang Kuan Hong KH Papaleo Francesco F
Cell reports 20160811 8
Human genetic studies have recently suggested that the postsynaptic activity-regulated cytoskeleton-associated protein (Arc) complex is a convergence signal for several genes implicated in schizophrenia. However, the functional significance of Arc in schizophrenia-related neurobehavioral phenotypes and brain circuits is unclear. Here, we find that, consistent with schizophrenia-related phenotypes, disruption of Arc in mice produces deficits in sensorimotor gating, cognitive functions, social beh ...[more]