Ontology highlight
ABSTRACT:
SUBMITTER: Tomasella E
PROVIDER: S-EPMC5879696 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Tomasella Eugenia E Bechelli Lucila L Ogando Mora Belén MB Mininni Camilo C Di Guilmi Mariano N MN De Fino Fernanda F Zanutto Silvano S Elgoyhen Ana Belén AB Marin-Burgin Antonia A Gelman Diego M DM
Proceedings of the National Academy of Sciences of the United States of America 20180312 13
Excessive dopamine neurotransmission underlies psychotic episodes as observed in patients with some types of bipolar disorder and schizophrenia. The dopaminergic hypothesis was postulated after the finding that antipsychotics were effective to halt increased dopamine tone. However, there is little evidence for dysfunction within the dopaminergic system itself. Alternatively, it has been proposed that excessive afferent activity onto ventral tegmental area dopaminergic neurons, particularly from ...[more]