Unknown

Dataset Information

0

Increased serum tumor necrosis factor ? levels in patients with lenalidomide-induced hypothyroidism.

ABSTRACT: As the use of lenalidomide expands, the poorly understood phenomenon of lenalidomide-induced thyroid abnormalities will increase. In this study, we compared rates of therapy-induced hypothyroidism in 329 patients with diffuse large B-cell lymphoma (DLBCL) treated with conventional chemotherapy (DLBCL-c) or conventional chemotherapy plus lenalidomide (DLBCL-len). We measured serum levels of tumor necrosis factor ?, interferon gamma, interleukin 6, interleukin 12, and interleukin 15 before and after treatment. We found a significantly higher rate of therapy-induced hypothyroidism in the DLBCL-len group (25.8% vs. 1.3%), and we found a statistically significant increase in serum tumor necrosis factor ? in patients with lenalidomide-induced hypothyroidism.

SUBMITTER: Iams WT 

PROVIDER: S-EPMC5002942 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Increased serum tumor necrosis factor α levels in patients with lenalidomide-induced hypothyroidism.

Iams Wade T WT   Hames Megan L ML   Tsai Judy P JP   Dahlman Kimberly B KB   Talbott Mahsa S MS   Richards Kristy L KL   Reddy Nishitha M NM  

Experimental hematology 20141028 2

As the use of lenalidomide expands, the poorly understood phenomenon of lenalidomide-induced thyroid abnormalities will increase. In this study, we compared rates of therapy-induced hypothyroidism in 329 patients with diffuse large B-cell lymphoma (DLBCL) treated with conventional chemotherapy (DLBCL-c) or conventional chemotherapy plus lenalidomide (DLBCL-len). We measured serum levels of tumor necrosis factor α, interferon gamma, interleukin 6, interleukin 12, and interleukin 15 before and aft  ...[more]

Similar Datasets

Unknown Association of increased levels of plasma tumor necrosis factor alpha with primary open-angle glaucoma.
| S-EPMC5905466 | biostudies-literature
Unknown High Serum Tumor Necrosis Factor-Alpha Levels in Women with Polycystic Ovary Syndrome: A Meta-Analysis.
| S-EPMC5072730 | biostudies-literature
Unknown Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.
| S-EPMC6236996 | biostudies-literature
Unknown Tumor necrosis factor alpha-induced inflammation is increased but apoptosis is inhibited by common food additive carrageenan.
| S-EPMC2998126 | biostudies-literature
Unknown Osteopontin Deficiency Suppresses Tumor Necrosis Factor-α-Induced Apoptosis in Chondrocytes.
| S-EPMC4297182 | biostudies-literature
Unknown Elevated levels of plasma tumor necrosis factor alpha in patients with pseudoexfoliation glaucoma.
| S-EPMC5775737 | biostudies-literature
Unknown Tumor Necrosis Factor Alpha-Induced Proteins in Malignant Tumors: Progress and Prospects.
| S-EPMC7182456 | biostudies-literature
Unknown Pentoxifylline reduces tumor necrosis factor-α and HIV-induced vascular endothelial activation.
| S-EPMC3448099 | biostudies-literature
Unknown Plasma Levels of Tumor Necrosis Factor Superfamily Molecules Are Increased in Bipolar Disorder.
| S-EPMC5565083 | biostudies-other
Unknown N-Acetylcysteine attenuates tumor necrosis factor alpha levels in autoimmune inner ear disease patients.
| S-EPMC4651738 | biostudies-literature