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Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.


ABSTRACT: BACKGROUND:Tumor necrosis factor alpha (TNF-?) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-? and disease severity in patients with IgAN remain controversial. METHODS:Concentrations of serum TNF-? of 147 patients with IgAN and 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations with clinicopathological features of patients with IgAN were evaluated. RESULTS:Serum levels of TNF-? [9.20 (7.70-10.60) pg/mL vs. 6.04 (5.11-7.23) pg/mL, P?

SUBMITTER: Li G 

PROVIDER: S-EPMC6236996 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Serum levels of tumor necrosis factor alpha in patients with IgA nephropathy are closely associated with disease severity.

Li Guanhong G   Wu Wei W   Zhang Xinyao X   Huang Yuan Y   Wen Yubing Y   Li Xuemei X   Gao Ruitong R  

BMC nephrology 20181114 1


<h4>Background</h4>Tumor necrosis factor alpha (TNF-α) is considered to play an important role in the pathogenesis in IgA nephropathy (IgAN). The correlations between serum TNF-α and disease severity in patients with IgAN remain controversial.<h4>Methods</h4>Concentrations of serum TNF-α of 147 patients with IgAN and 126 healthy subjects were measured by chemiluminescence immunoassay. Correlations with clinicopathological features of patients with IgAN were evaluated.<h4>Results</h4>Serum levels  ...[more]

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