Ontology highlight
ABSTRACT:
SUBMITTER: Kallolimath S
PROVIDER: S-EPMC5003249 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Kallolimath Somanath S Castilho Alexandra A Strasser Richard R Grünwald-Gruber Clemens C Altmann Friedrich F Strubl Sebastian S Galuska Christina Elisabeth CE Zlatina Kristina K Galuska Sebastian Peter SP Werner Stefan S Thiesler Hauke H Werneburg Sebastian S Hildebrandt Herbert H Gerardy-Schahn Rita R Steinkellner Herta H
Proceedings of the National Academy of Sciences of the United States of America 20160721 34
Sialic acids (Sias) are abundant terminal modifications of protein-linked glycans. A unique feature of Sia, compared with other monosaccharides, is the formation of linear homo-polymers, with its most complex form polysialic acid (polySia). Sia and polySia mediate diverse biological functions and have great potential for therapeutic use. However, technological hurdles in producing defined protein sialylation due to the enormous structural diversity render their precise investigation a challenge. ...[more]