Cellular and Molecular Engineering of Glycan Sialylation in Heterologous Systems.

ABSTRACT: Glycans have been shown to play a key role in many biological processes, such as signal transduction, immunogenicity, and disease progression. Among the various glycosylation modifications found on cell surfaces and in biomolecules, sialylation is especially important, because sialic acids are typically found at the terminus of glycans and have unique negatively charged moieties associated with cellular and molecular interactions. Sialic acids are also crucial for glycosylated biopharmaceutics, where they promote stability and activity. In this regard, heterogenous sialylation may produce variability in efficacy and limit therapeutic applications. Homogenous sialylation may be achieved through cellular and molecular engineering, both of which have gained traction in recent years. In this p

SUBMITTER: Hombu R 

PROVIDER: S-EPMC8512710 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature