HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
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ABSTRACT:
SUBMITTER: Kessl JJ
PROVIDER: S-EPMC5003418 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
HIV-1 Integrase Binds the Viral RNA Genome and Is Essential during Virion Morphogenesis.
Kessl Jacques J JJ Kutluay Sebla B SB Townsend Dana D Rebensburg Stephanie S Slaughter Alison A Larue Ross C RC Shkriabai Nikoloz N Bakouche Nordine N Fuchs James R JR Bieniasz Paul D PD Kvaratskhelia Mamuka M
Cell 20160801 5
While an essential role of HIV-1 integrase (IN) for integration of viral cDNA into human chromosome is established, studies with IN mutants and allosteric IN inhibitors (ALLINIs) have suggested that IN can also influence viral particle maturation. However, it has remained enigmatic as to how IN contributes to virion morphogenesis. Here, we demonstrate that IN directly binds the viral RNA genome in virions. These interactions have specificity, as IN exhibits distinct preference for select viral R ...[more]
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