Ontology highlight
ABSTRACT:
SUBMITTER: Simonato M
PROVIDER: S-EPMC5003536 | biostudies-literature | 2014 Sep
REPOSITORIES: biostudies-literature
Simonato Michele M Brooks-Kayal Amy R AR Engel Jerome J Galanopoulou Aristea S AS Jensen Frances E FE Moshé Solomon L SL O'Brien Terence J TJ Pitkanen Asla A Wilcox Karen S KS French Jacqueline A JA
The Lancet. Neurology 20140810 9
Translation of successful target and compound validation studies into clinically effective therapies is a major challenge, with potential for costly clinical trial failures. This situation holds true for the epilepsies-complex diseases with different causes and symptoms. Although the availability of predictive animal models has led to the development of effective antiseizure therapies that are routinely used in clinical practice, showing that translation can be successful, several important unme ...[more]