Dataset Information

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

ABSTRACT:

Purpose/objectives

Radiation injury to parahippocampal cingulum white matter is associated with cognitive decline. Diffusion tensor imaging (DTI) detects micropathologic changes in white matter. Increased radial diffusion (RD) and decreased axial diffusion (AD) correspond to demyelination and axonal degeneration/gliosis respectively. We aimed to develop a predictive model for radiation-induced cognitive changes based upon DTI changes.

Materials/methods

Twenty-seven adults with benign or low-grade tumors received partial brain radiation therapy (RT) to a median dose of 54Gy. Patients underwent DTI before RT, during RT, and at the end of RT. Cognitive testing was performed before RT, and 6 and 18months after RT. Parahippocampal cingulum white matter was contoured to obtain mean values of AD and RD.

Results

By univariate analysis, decreasing AD and increasing RD during RT predicted declines in verbal memory and verbal fluency. By multivariate analysis, baseline neurocognitive score was the only clinical variable predicting verbal memory change; no clinical variables predicted verbal fluency change. In a multivariate model, increased RD at the end of RT significantly predicted decline in verbal fluency 18months after RT.

Conclusions

Imaging biomarkers of white matter injury contributed to predictive models of cognitive function change after RT.

SUBMITTER: Chapman CH

PROVIDER: S-EPMC5003665 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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Publications

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

Chapman Christopher H CH Zhu Tong T Nazem-Zadeh Mohamad M Tao Yebin Y Buchtel Henry A HA Tsien Christina I CI Lawrence Theodore S TS Cao Yue Y

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 20160711 2

<h4>Purpose/objectives</h4>Radiation injury to parahippocampal cingulum white matter is associated with cognitive decline. Diffusion tensor imaging (DTI) detects micropathologic changes in white matter. Increased radial diffusion (RD) and decreased axial diffusion (AD) correspond to demyelination and axonal degeneration/gliosis respectively. We aimed to develop a predictive model for radiation-induced cognitive changes based upon DTI changes.<h4>Materials/methods</h4>Twenty-seven adults with ben ...[more]

PMID: 27418525

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Dataset Information

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

Purpose/objectives

Materials/methods

Results

Conclusions

Publications

Diffusion tensor imaging predicts cognitive function change following partial brain radiotherapy for low-grade and benign tumors.

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