Ontology highlight
ABSTRACT:
SUBMITTER: Yuen DA
PROVIDER: S-EPMC5004640 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Yuen Darren A DA Huang Yi-Wei YW Liu Guang-Ying GY Patel Sajedabanu S Fang Fei F Zhou Joyce J Thai Kerri K Sidiqi Ahmad A Szeto Stephen G SG Chan Lauren L Lu Mingliang M He Xiaolin X John Rohan R Gilbert Richard E RE Scholey James W JW Robinson Lisa A LA
Journal of the American Society of Nephrology : JASN 20160211 9
Fibrosis and inflammation are closely intertwined injury pathways present in nearly all forms of CKD for which few safe and effective therapies exist. Slit glycoproteins signaling through Roundabout (Robo) receptors have been described to have anti-inflammatory effects through regulation of leukocyte cytoskeletal organization. Notably, cytoskeletal reorganization is also required for fibroblast responses to TGF-β Here, we examined whether Slit2 also controls TGF-β-induced renal fibrosis. In cult ...[more]