Ontology highlight
ABSTRACT:
SUBMITTER: He X
PROVIDER: S-EPMC5004882 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
He Xinjun X Ohba Shinsuke S Hojo Hironori H McMahon Andrew P AP
Development (Cambridge, England) 20160728 16
An analysis of Sox9 binding profiles in developing chondrocytes identified marked enrichment of an AP-1-like motif. Here, we have explored the functional interplay between Sox9 and AP-1 in mammalian chondrocyte development. Among AP-1 family members, Jun and Fosl2 were highly expressed within prehypertrophic and early hypertrophic chondrocytes. Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) showed a striking overlap in Jun- and Sox9-bound regions throughout the chondrocyte g ...[more]