Ontology highlight
ABSTRACT:
SUBMITTER: Garces de Los Fayos Alonso I
PROVIDER: S-EPMC5923348 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Garces de Los Fayos Alonso Ines I Liang Huan-Chang HC Turner Suzanne D SD Lagger Sabine S Merkel Olaf O Kenner Lukas L
Cancers 20180328 4
The Activator Protein-1 (AP-1) transcription factor (TF) family, composed of a variety of members including c-JUN, c-FOS and ATF, is involved in mediating many biological processes such as proliferation, differentiation and cell death. Since their discovery, the role of AP-1 TFs in cancer development has been extensively analysed. Multiple in vitro and in vivo studies have highlighted the complexity of these TFs, mainly due to their cell-type specific homo- or hetero-dimerization resulting in di ...[more]