Ontology highlight
ABSTRACT:
SUBMITTER: Wang S
PROVIDER: S-EPMC5006124 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Wang Shanshan S Chen Yongzhi Y Li Chunfeng C Wu Yaoxing Y Guo Lei L Peng Changwei C Huang Yueping Y Cheng Genhong G Qin F Xiao-Feng FX
Scientific reports 20160831
Tripartite motif 14 (TRIM14) was reported to function as a mitochondrial signaling adaptor in mediating innate immune responses. However, the involvement of TRIM14 in host defense against viral infection and molecular mechanisms remain unclear. Here, we demonstrated that enforced expression of TRIM14 could potently inhibit the infection and replication of HCV in hepatocytes, whereas TRIM14 knockout cells became more susceptible to HCV infection. Interestingly, further experiments revealed that s ...[more]