Embracing rejection: Immunologic trends in brain metastasis.
Ontology highlight
ABSTRACT:
SUBMITTER: Farber SH
PROVIDER: S-EPMC5006920 | biostudies-literature | 2016 Jul
REPOSITORIES: biostudies-literature
Publications
Embracing rejection: Immunologic trends in brain metastasis.
Farber S Harrison SH Tsvankin Vadim V Narloch Jessica L JL Kim Grace J GJ Salama April K S AK Vlahovic Gordana G Blackwell Kimberly L KL Kirkpatrick John P JP Fecci Peter E PE
Oncoimmunology 20160411 7
Brain metastases represent the most common type of brain tumor. These tumors offer a dismal prognosis and significantly impact quality of life for patients. Their capacity for central nervous system (CNS) invasion is dependent upon induced disruptions to the blood-brain barrier (BBB), alterations to the brain microenvironment, and mechanisms for escaping CNS immunosurveillance. In the emerging era of immunotherapy, understanding how metastases are influenced by the immunologic peculiarities of t ...[more]
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