Ontology highlight
ABSTRACT:
SUBMITTER: Zhou K
PROVIDER: S-EPMC5007158 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Zhou Kaixin K Yee Sook Wah SW Seiser Eric L EL van Leeuwen Nienke N Tavendale Roger R Bennett Amanda J AJ Groves Christopher J CJ Coleman Ruth L RL van der Heijden Amber A AA Beulens Joline W JW de Keyser Catherine E CE Zaharenko Linda L Rotroff Daniel M DM Out Mattijs M Jablonski Kathleen A KA Chen Ling L Javorský Martin M Židzik Jozef J Levin Albert M AM Williams L Keoki LK Dujic Tanja T Semiz Sabina S Kubo Michiaki M Chien Huan-Chieh HC Maeda Shiro S Witte John S JS Wu Longyang L Tkáč Ivan I Kooy Adriaan A van Schaik Ron H N RHN Stehouwer Coen D A CDA Logie Lisa L Logie Lisa L Sutherland Calum C Klovins Janis J Pirags Valdis V Hofman Albert A Stricker Bruno H BH Motsinger-Reif Alison A AA Wagner Michael J MJ Innocenti Federico F 't Hart Leen M LM Holman Rury R RR McCarthy Mark I MI Hedderson Monique M MM Palmer Colin N A CNA Florez Jose C JC Giacomini Kathleen M KM Pearson Ewan R ER
Nature genetics 20160808 9
Metformin is the first-line antidiabetic drug with over 100 million users worldwide, yet its mechanism of action remains unclear. Here the Metformin Genetics (MetGen) Consortium reports a three-stage genome-wide association study (GWAS), consisting of 13,123 participants of different ancestries. The C allele of rs8192675 in the intron of SLC2A2, which encodes the facilitated glucose transporter GLUT2, was associated with a 0.17% (P = 6.6 × 10(-14)) greater metformin-induced reduction in hemoglob ...[more]