Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Perez R
PROVIDER: S-EPMC5007171 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Pérez-Pérez Rafael R Lobo-Jarne Teresa T Milenkovic Dusanka D Mourier Arnaud A Bratic Ana A García-Bartolomé Alberto A Fernández-Vizarra Erika E Cadenas Susana S Delmiro Aitor A García-Consuegra Inés I Arenas Joaquín J Martín Miguel A MA Larsson Nils-Göran NG Ugalde Cristina C
Cell reports 20160818 9
Mitochondrial respiratory chain (MRC) complexes I, III, and IV associate into a variety of supramolecular structures known as supercomplexes and respirasomes. While COX7A2L was originally described as a supercomplex-specific factor responsible for the dynamic association of complex IV into these structures to adapt MRC function to metabolic variations, this role has been disputed. Here, we further examine the functional significance of COX7A2L in the structural organization of the mammalian resp ...[more]