Ontology highlight
ABSTRACT:
SUBMITTER: Steventon JJ
PROVIDER: S-EPMC5007531 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Steventon Jessica J JJ Trueman Rebecca C RC Ma Da D Yhnell Emma E Bayram-Weston Zubeyde Z Modat Marc M Cardoso Jorge J Ourselin Sebastian S Lythgoe Mark M Stewart Andrew A Rosser Anne E AE Jones Derek K DK
Scientific reports 20160901
Huntington's disease (HD) is a genetically-determined neurodegenerative disease. Characterising neuropathology in mouse models of HD is commonly restricted to cross-sectional ex vivo analyses, beset by tissue fixation issues. In vivo longitudinal magnetic resonance imaging (MRI) allows for disease progression to be probed non-invasively. In the HdhQ150 mouse model of HD, in vivo MRI was employed at two time points, before and after the onset of motor signs, to assess brain macrostructure and whi ...[more]