Ontology highlight
ABSTRACT:
SUBMITTER: Stoica R
PROVIDER: S-EPMC5007559 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Stoica Radu R Paillusson Sébastien S Gomez-Suaga Patricia P Mitchell Jacqueline C JC Lau Dawn Hw DH Gray Emma H EH Sancho Rosa M RM Vizcay-Barrena Gema G De Vos Kurt J KJ Shaw Christopher E CE Hanger Diane P DP Noble Wendy W Miller Christopher Cj CC
EMBO reports 20160714 9
Defective FUS metabolism is strongly associated with amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD), but the mechanisms linking FUS to disease are not properly understood. However, many of the functions disrupted in ALS/FTD are regulated by signalling between the endoplasmic reticulum (ER) and mitochondria. This signalling is facilitated by close physical associations between the two organelles that are mediated by binding of the integral ER protein VAPB to the outer mitocho ...[more]