Improving vaccine efficacy against malignant glioma.
Ontology highlight
ABSTRACT:
SUBMITTER: Ladomersky E
PROVIDER: S-EPMC5007967 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Publications
Improving vaccine efficacy against malignant glioma.
Ladomersky Erik E Genet Matthew M Zhai Lijie L Gritsina Galina G Lauing Kristen L KL Lulla Rishi R RR Fangusaro Jason J Lenzen Alicia A Kumthekar Priya P Raizer Jeffrey J JJ Binder David C DC James C David CD Wainwright Derek A DA
Oncoimmunology 20160610 8
The effective treatment of adult and pediatric malignant glioma is a significant clinical challenge. In adults, glioblastoma (GBM) accounts for the majority of malignant glioma diagnoses with a median survival of 14.6 mo. In children, malignant glioma accounts for 20% of primary CNS tumors with a median survival of less than 1 y. Here, we discuss vaccine treatment for children diagnosed with malignant glioma, through targeting EphA2, IL-13Rα2 and/or histone H3 K27M, while in adults, treatments w ...[more]
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