Ontology highlight
ABSTRACT:
SUBMITTER: Hong X
PROVIDER: S-EPMC5008346 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Hong Xuehui X Xu Yang Y Qiu Xingfeng X Zhu Yuekun Y Feng Xing X Ding Zhijie Z Zhang Shifeng S Zhong Lifeng L Zhuang Yifan Y Su Chen C Hong Xinya X Cai Jianchun J
Oncotarget 20160401 16
MicroRNAs are critical in various human cancers, including gastric cancer (GC). However, the mechanism underlying the GC development remains elusive. In this study, we demonstrate that miR-448 is increased in GC samples and cell lines. Overexpression of miR-448 facilitated the proliferation of GC cells by stimulating glycolysis. Mechanistically, we identified KDM2B, a reader for methylated CpGs, as the target of miR-448 that represses glycolysis and promotes oxidative phosphorylation. Overexpres ...[more]