Ontology highlight
ABSTRACT:
SUBMITTER: Piao L
PROVIDER: S-EPMC5008405 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Piao Lianhua L Nakakido Makoto M Suzuki Takehiro T Dohmae Naoshi N Nakamura Yusuke Y Hamamoto Ryuji R
Oncotarget 20160401 16
We previously reported that the histone lysine methyltransferase SUV39H2, which is overexpressed in various types of human cancer, plays a critical role in the DNA repair after double strand breakage, and possesses oncogenic activity. Although its biological significance in tumorigenesis has been elucidated, the regulatory mechanism of SUV39H2 activity through post-translational modification is not well known. In this study, we demonstrate in vitro and in vivo automethylation of SUV39H2 at lysin ...[more]