Ontology highlight
ABSTRACT:
SUBMITTER: Angelici B
PROVIDER: S-EPMC5009115 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Angelici Bartolomeo B Mailand Erik E Haefliger Benjamin B Benenson Yaakov Y
Cell reports 20160818 9
One of the goals of synthetic biology is to develop programmable artificial gene networks that can transduce multiple endogenous molecular cues to precisely control cell behavior. Realizing this vision requires interfacing natural molecular inputs with synthetic components that generate functional molecular outputs. Interfacing synthetic circuits with endogenous mammalian transcription factors has been particularly difficult. Here, we describe a systematic approach that enables integration and t ...[more]