Ontology highlight
ABSTRACT:
SUBMITTER: Imae K
PROVIDER: S-EPMC5009239 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Imae Kenta K Saito Yuki Y Kizaki Hayato H Ryuno Hiroki H Mao Han H Miyashita Atsushi A Suzuki Yutaka Y Sekimizu Kazuhisa K Kaito Chikara C
The Journal of biological chemistry 20160715 36
We identified SA1684 as a Staphylococcus aureus virulence gene using a silkworm infection model. The SA1684 gene product carried the DUF402 domain, which is found in RNA-binding proteins, and had amino acid sequence similarity with a nucleoside diphosphatase, Streptomyces coelicolor SC4828 protein. The SA1684-deletion mutant exhibited drastically decreased virulence, in which the LD50 against silkworms was more than 10 times that of the parent strain. The SA1684-deletion mutant also exhibited de ...[more]