Ontology highlight
ABSTRACT:
SUBMITTER: Mikheyeva IV
PROVIDER: S-EPMC6458089 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Mikheyeva Irina V IV Thomas Jason M JM Kolar Stacey L SL Corvaglia Anna-Rita AR Gaϊa Nadia N Leo Stefano S Francois Patrice P Liu George Y GY Rawat Mamta M Cheung Ambrose L AL
Molecular microbiology 20190217 4
The intracellular redox environment of Staphylococcus aureus is mainly buffered by bacillithiol (BSH), a low molecular weight thiol. The identity of enzymes responsible for the recycling of oxidized bacillithiol disulfide (BSSB) to the reduced form (BSH) remains elusive. We examined YpdA, a putative bacillithiol reductase, for its role in maintaining intracellular redox homeostasis. The ypdA mutant showed increased levels of BSSB and a lower bacillithiol redox ratio vs. the isogenic parent, indi ...[more]