Ontology highlight
ABSTRACT:
SUBMITTER: Shih HT
PROVIDER: S-EPMC5010193 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Shih Hsueh-Tzu HT Chen Wei-Yu WY Liu Kwei-Yan KY Shih Zong-Siou ZS Chen Yi-Jyun YJ Hsieh Paul-Chen PC Kuo Kuan-Lin KL Huang Kuo-How KH Hsu Pang-Hung PH Liu Ya-Wen YW Chan Shih-Peng SP Lee Hsiu-Hsiang HH Tsai Yu-Chen YC Wu June-Tai JT
PLoS genetics 20160902 9
To maintain a particular cell fate, a unique set of genes should be expressed while another set is repressed. One way to repress gene expression is through Polycomb group (PcG) proteins that compact chromatin into a silent configuration. In addition to cell fate maintenance, PcG proteins also maintain normal cell physiology, for example cell cycle. In the absence of PcG, ectopic activation of the PcG-repressed genes leads to developmental defects and malignant tumors. Little is known about the m ...[more]