Ontology highlight
ABSTRACT:
SUBMITTER: Doedens AL
PROVIDER: S-EPMC5010943 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Doedens Andrew L AL Rubinstein Mark P MP Gross Emilie T ET Best J Adam JA Craig David H DH Baker Megan K MK Cole David J DJ Bui Jack D JD Goldrath Ananda W AW
Cancer immunology research 20160802 9
Despite clinical potential and recent advances, durable immunotherapeutic ablation of solid tumors is not routinely achieved. IL15 expands natural killer cell (NK), natural killer T cell (NKT) and CD8(+) T-cell numbers and engages the cytotoxic program, and thus is under evaluation for potentiation of cancer immunotherapy. We found that short-term therapy with IL15 bound to soluble IL15 receptor α-Fc (IL15cx; a form of IL15 with increased half-life and activity) was ineffective in the treatment ...[more]