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PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

ABSTRACT: The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy as a cell survival strategy during stress conditions. These findings demonstrate that autophagy inhibition could be paired with a chemotherapeutic agent to develop anticancer strategies for tumors that present PML downregulation.

SUBMITTER: Missiroli S

PROVIDER: S-EPMC5011426 | biostudies-literature | 2016 Aug

REPOSITORIES: biostudies-literature

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PML at Mitochondria-Associated Membranes Is Critical for the Repression of Autophagy and Cancer Development.

Missiroli Sonia S Bonora Massimo M Patergnani Simone S Poletti Federica F Perrone Mariasole M Gafà Roberta R Magri Eros E Raimondi Andrea A Lanza Giovanni G Tacchetti Carlo C Kroemer Guido G Pandolfi Pier Paolo PP Pinton Paolo P Giorgi Carlotta C

Cell reports 20160818 9

The precise molecular mechanisms that coordinate apoptosis and autophagy in cancer remain to be determined. Here, we provide evidence that the tumor suppressor promyelocytic leukemia protein (PML) controls autophagosome formation at mitochondria-associated membranes (MAMs) and, thus, autophagy induction. Our in vitro and in vivo results demonstrate how PML functions as a repressor of autophagy. PML loss promotes tumor development, providing a growth advantage to tumor cells that use autophagy as ...[more]

PMID: 27545895

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2024-08-26 | GSE273383 | GEO

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