Ontology highlight
ABSTRACT:
SUBMITTER: Morgan AP
PROVIDER: S-EPMC5012392 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Morgan Andrew P AP Holt J Matthew JM McMullan Rachel C RC Bell Timothy A TA Clayshulte Amelia M-F AM Didion John P JP Yadgary Liran L Thybert David D Odom Duncan T DT Flicek Paul P McMillan Leonard L de Villena Fernando Pardo-Manuel FP
Genetics 20160702 1
Gene duplication and loss are major sources of genetic polymorphism in populations, and are important forces shaping the evolution of genome content and organization. We have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies reveals that they have been subject to nonallelic gene conversion events spanning tens ...[more]