Ontology highlight
ABSTRACT:
SUBMITTER: Bouty A
PROVIDER: S-EPMC5012964 | biostudies-literature | 2015
REPOSITORIES: biostudies-literature
Bouty Aurore A Ayers Katie L KL Pask Andrew A Heloury Yves Y Sinclair Andrew H AH
Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 20151128 5
Hypospadias results from a failure of urethral closure in the male phallus and affects 1 in 200-300 boys. It is thought to be due to a combination of genetic and environmental factors. The development of the penis progresses in 2 stages: an initial hormone-independent phase and a secondary hormone-dependent phase. Here, we review the molecular pathways that contribute to each of these stages, drawing on studies from both human and mouse models. Hypospadias can occur when normal development of th ...[more]