Ontology highlight
ABSTRACT:
SUBMITTER: Guan H
PROVIDER: S-EPMC5013389 | biostudies-literature | 2016 Sep
REPOSITORIES: biostudies-literature
Guan Hongtao H Shuaib Aban A Leon David Davila De DD Angyal Adrienn A Salazar Maria M Velasco Guillermo G Holcombe Mike M Dower Steven K SK Kiss-Toth Endre E
Scientific reports 20160907
Spatio-temporal regulation of intracellular signalling networks is key to normal cellular physiology; dysregulation of which leads to disease. The family of three mammalian tribbles proteins has emerged as an important controller of signalling via regulating the activity of mitogen activated protein kinases (MAPK), the PI3-kinase induced signalling network and E3 ubiquitin ligases. However, the importance of potential redundancy in the action of tribbles and how the differences in affinities for ...[more]