Ontology highlight
ABSTRACT:
SUBMITTER: Huffman DL
PROVIDER: S-EPMC503732 | biostudies-literature | 2004 Jul
REPOSITORIES: biostudies-literature
Huffman Danielle L DL Abrami Laurence L Sasik Roman R Corbeil Jacques J van der Goot F Gisou FG Aroian Raffi V RV
Proceedings of the National Academy of Sciences of the United States of America 20040715 30
Cytolytic pore-forming toxins are important for the virulence of many disease-causing bacteria. How target cells molecularly respond to these toxins and whether or not they can mount a defense are poorly understood. By using microarrays, we demonstrate that the nematode Caenorhabditis elegans responds robustly to Cry5B, a member of the pore-forming Crystal toxin family made by Bacillus thuringiensis. This genomic response is distinct from that seen with a different stressor, the heavy metal cadm ...[more]