Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC5014612 | biostudies-literature | 2016 Oct
REPOSITORIES: biostudies-literature
Zhang Xiaojie X Wang Rubing R Perez German Ruiz GR Chen Guanglin G Zhang Qiang Q Zheng Shilong S Wang Guangdi G Chen Qiao-Hong QH
Bioorganic & medicinal chemistry 20160806 19
In search of more effective chemotherapeutics for the treatment of castration-resistant prostate cancer and inspired by curcumin analogues, twenty five (1E,3E,6E,8E)-1,9-diarylnona-1,3,6,8-tetraen-5-ones bearing two identical terminal heteroaromatic rings have been successfully synthesized through Wittig reaction followed by Horner-Wadsworth-Emmons reaction. Twenty-three of them are new compounds. The WST-1 cell proliferation assay was employed to assess their anti-proliferative effects toward b ...[more]